Discovery of histamine h 2 receptor antagonists the discovery of histamine h 2 antagonists is a story of single minded commitment by a group of creative scientists working in close collaboration in the united kingdomthe process of research and development for economical production of the resulting drug cimetidine was the work of equally creative scientists working in the united states. The synthesis of and pharmacological studies on selective agonists and antagonists has established the existence of four types of histamine receptor and histamine receptor antagonists have found very important therapeutic applications. The h2 blockers are specific antagonists of the histamine type 2 receptor which is found on the basolateral antiluminal membrane of gastric parietal cells the binding of famotidine to the h2 receptor results in inhibition of acid production and secretion and improvement in symptoms and signs of acid peptic disease. Competitive antagonists with a high degree of selectivity for the h2 receptor and with a longer duration of action are currently being investigated eg sufotidine
How it works:
1. Register a Free 1 month Trial Account.
2. Download as many books as you like ( Personal use )
3. No Commitment. Cancel anytime.
4. Join Over 100.000 Happy Readers.
5. That's it. What you waiting for? Sign Up and Get Your Books.